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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Preclinical Development: Overview01:28

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Study Designs in Epidemiology01:20

Study Designs in Epidemiology

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Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
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Current Trends in Nursing II01:30

Current Trends in Nursing II

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Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
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Related Experiment Video

Updated: Aug 14, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
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Using Patient Perspectives to Inform Better Clinical Trial Design and Conduct: Current Trends and Future Directions.

Stuart D Faulkner1, Fabian Somers2, Mathieu Boudes3

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Patient engagement in drug development is evolving due to complex medicines, technology, and a focus on patient needs. This trend is improving clinical trial design and patient-centricity.

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Area of Science:

  • Drug development
  • Clinical research
  • Patient engagement

Background:

  • Evolving landscape of drug development driven by complex innovative drugs.
  • Increasing need to demonstrate patient-relevant outcomes and the value of patient engagement (PE).
  • Impact of the COVID-19 pandemic on clinical trial operations, including decentralised studies.

Purpose of the Study:

  • To reflect on recent changes and emerging trends in patient engagement within clinical research.
  • To analyze the drivers behind the transformation of patient engagement strategies.
  • To anticipate the future progression of patient engagement in clinical research.

Main Methods:

  • Analysis of technological advancements in clinical trial management and data capture.
  • Consideration of societal demands for diversity, inclusion, efficiency, transparency, and accountability.
  • Review of organizational efforts to monitor and learn from patient engagement activities and outcomes.

Main Results:

  • Patient engagement is increasingly incorporating patients' lived experiences, preferences, and needs into trial design and execution.
  • Technological advancements are facilitating new methods for capturing patient-reported outcomes and preferences.
  • Growing emphasis on diversity, inclusion, and efficiency is shaping patient engagement strategies.

Conclusions:

  • Patient engagement in clinical research is undergoing significant transformation.
  • The integration of patient perspectives is becoming more central to drug development.
  • Future patient engagement strategies will likely be more data-driven, inclusive, and patient-centric.