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Antibiotic Susceptibility Profile for the US Neisseria meningitidis Urethritis Clade

Jose A Bazan1,2, Yih-Ling Tzeng3, Katarina M Bischof4

  • 1Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA.

Open Forum Infectious Diseases
|January 19, 2023
PubMed

Insights

The US Neisseria meningitidis urethritis clade (US_NmUC) causes gonorrhea-like symptoms and contains gonococcal DNA. Fortunately, US_NmUC isolates remain susceptible to recommended antibiotics for gonorrhea and meningococcal disease prevention.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • The US Neisseria meningitidis urethritis clade (US_NmUC) is an emerging pathogen.
  • US_NmUC infections present as gonorrhea-like urogenital tract disease.
  • US_NmUC harbors gonococcal deoxyribonucleic acid alleles.

Purpose of the Study:

  • To assess the antibiotic susceptibility of US_NmUC isolates.
  • To determine if US_NmUC remains susceptible to current gonorrhea treatment and meningococcal chemoprophylaxis regimens.

Main Methods:

  • Analysis of 122 US_NmUC isolates collected in Columbus, Ohio.
  • Isolates were collected between January 2015 and December 2019.
  • Antibiotic susceptibility testing was performed.

Main Results:

  • All 122 US_NmUC isolates demonstrated uniform susceptibility to antibiotics.
  • Susceptibility was observed for antibiotics recommended for gonorrhea treatment.
  • Susceptibility was also observed for antibiotics used in meningococcal chemoprophylaxis.

Conclusions:

  • US_NmUC remains uniformly susceptible to key antibiotics.
  • Current antibiotic recommendations for gonorrhea and meningococcal chemoprophylaxis are likely effective against US_NmUC.
  • This finding is crucial for guiding treatment and prevention strategies.
Keywords:
Neisseria sppUS_NmUCantibiotic resistanceantibiotic susceptibilityurethritis

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