Higher serum triglyceride can predict recurrent coronary revascularization events in patients undergoing percutaneous...

Area of Science:

• Cardiology
• Vascular Medicine
• Biochemistry

Background:

• Recurrent coronary revascularization events in patients with low baseline low-density lipoprotein cholesterol (LDL-C) are understudied.
• Percutaneous coronary intervention (PCI) is a common procedure, but long-term outcomes in specific patient subgroups require further investigation.

Purpose of the Study:

• To investigate the predictors of recurrent coronary revascularization events and all-cause death in patients with baseline LDL-C <55 mg/dL undergoing PCI.
• To identify clinical characteristics associated with adverse cardiovascular outcomes in this specific patient population.

Main Methods:

• Retrospective cohort study of 388 patients undergoing PCI with baseline LDL-C <55 mg/dL.
• Follow-up for 4 years to document ischemia-driven coronary revascularization events and all-cause death.
• Multivariate Cox and Kaplan-Meier analyses were used to evaluate predictors of long-term events.

Main Results:

• Higher baseline serum triglyceride (TG) levels (≥1.17 mmol/L) were an independent predictor of recurrent coronary revascularization events (HR 1.691, p=0.004).
• Female sex (HR 2.647, p=0.005) and previous atrial fibrillation (HR 3.163, p=0.006) were associated with increased risk of all-cause death.
• 32 patients experienced recurrent revascularization, and 38 patients died from all causes during follow-up.

Conclusions:

• In patients undergoing PCI with low baseline LDL-C, elevated serum triglyceride levels are a significant predictor of recurrent coronary revascularization.
• These findings highlight the importance of TG management in this high-risk group.
• Female sex and atrial fibrillation are risk factors for all-cause mortality in this cohort.