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Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular

Li-Peng Li1, Hao-Xin Li1, Hui Zhou1

  • 1Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, People's Republic of China.

Journal of Biomolecular Structure & Dynamics
|January 19, 2023
PubMed
Summary

The CDC25B C473D mutation weakens binding to CDK2/CyclinA by reducing system stability and altering key residue interactions. This study clarifies the mechanism behind reduced affinity in the CDC25B C473D mutant, impacting cancer development research.

Keywords:
C473D mutationCDC25BCDK2/CyclinAmolecular dynamics studyweak binding affinity

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