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Related Experiment Video

Updated: Aug 13, 2025

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

An integrated microbiome project for charactering microbial diversity in classroom based on virtual simulation

Hao Sun¹, Pinmei Wang², Yudong Li¹

¹Department of Biological Engineering, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China.

Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology

|January 19, 2023

Summary

This study introduces a virtual lab to teach microbiome concepts and bioinformatics skills to undergraduates. The virtual lab improved students' laboratory techniques and research capabilities, enhancing their learning outcomes.

Keywords:

16S rRNA VSEARCH metagenomics microbiome virtual lab

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Published on: July 4, 2018

Area of Science:

Microbiology
Bioinformatics
Science Education

Background:

Microbiome research demands specialized molecular and bioinformatics skills, posing challenges for biologists.
Undergraduate science education needs effective methods to introduce complex microbiome concepts and techniques.

Purpose of the Study:

To develop and evaluate a 6-week project-based learning (PBL) course integrating wet-lab and bioinformatics components for undergraduate microbiome education.
To assess the impact of a novel virtual simulation lab on student learning outcomes in microbiome research.

Main Methods:

Implemented a 6-week PBL course focused on saliva microbiome analysis.
Students utilized a virtual simulation lab for practicing molecular and bioinformatics techniques.
Conducted 16S rRNA gene amplicon sequencing for metagenomic analysis of student-collected saliva samples.

Main Results:

The virtual lab significantly improved students' laboratory techniques and research capabilities.
A simplified bioinformatics pipeline effectively trained students in 16S rRNA gene amplicon data analysis.
Student learning outcomes demonstrated the positive impact of the virtual lab on science education.

Conclusions:

Virtual labs are effective tools for enhancing undergraduate learning in microbiome science.
The PBL approach combined with virtual simulation provides a robust framework for microbiome education.
This course module can be adapted for various undergraduate biology and bioinformatics programs.