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Drug-induced aseptic meningitis

Camilla Ågnes1, Thomas Schwartz2, Else Quist-Paulsen3

  • 1Indremedisinsk avdeling, og, Enhet for indremedisinsk forskning, Medisinsk klinikk, Oslo universitetssykehus, Ullevål sykehus.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|January 19, 2023
PubMed

Insights

Drug-induced aseptic meningitis is a rare condition. Suspect it in patients with meningitis symptoms and negative microbiological tests, especially after drug exposure.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pharmacology

Background:

  • Drug-induced aseptic meningitis is a rare but serious adverse drug reaction.
  • It presents with meningitis symptoms but lacks microbiological evidence of infection.
  • Recurrent urinary tract infections can lead to repeated exposure to certain medications.

Purpose of the Study:

  • To highlight the importance of considering drug-induced aseptic meningitis in differential diagnosis.
  • To present a case study of a patient with recurrent meningitis symptoms linked to drug exposure.
  • To emphasize the need for thorough medical history in diagnosing aseptic meningitis.

Main Methods:

  • Case report presentation.
  • Review of patient's medical history, focusing on drug exposure and symptom onset.
  • Differential diagnosis process for meningitis.

Main Results:

  • The patient presented with recurrent meningitis symptoms.
  • Symptoms resolved upon discontinuation of the suspected drug and recurred upon re-exposure.
  • Microbiological tests for meningitis were consistently negative.

Conclusions:

  • Drug-induced aseptic meningitis should be suspected in cases of unexplained meningitis, particularly with negative infectious workups.
  • A detailed drug history is crucial for diagnosing this condition.
  • Prompt recognition and drug withdrawal can lead to favorable outcomes.

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