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Low serum creatinine, a surrogate marker of muscle mass, correlates with insulin sensitivity in nonhuman primates
Uddhav K Chaudhari1,2, Barbara C Hansen2
1Department of Cell Physiology and Pathology, ICMR-National Institute for Research in Reproductive Child Health, Mumbai, India.
Objectives:
Decreased serum creatinine levels are associated with increased risk of type 2 diabetes (T2DM) in humans, however, its association with muscle mass and insulin sensitivity have not been studied in NHPs.
Methods:
Retrospective data of 229 adult NHPs were studied for association of serum creatinine levels with muscle mass and onset of T2DM.
Results:
Serum creatinine levels were positively correlated with lean muscle mass in nondiabetic (non-DM), male and female NHPs. Aged NHPs had significantly reduced lean muscle mass and corresponding creatinine levels compared to young age groups (p < .001). Creatinine was positively correlated with insulin sensitivity in nonDM male NHPs and significant decrease in creatinine was observed in T2DM (p < .001) compared to same age group nonDM NHPs.
Conclusions:
The pathophysiology of T2DM in NHPs is similar to humans, low creatinine further provides utility of surrogate biomarkers of lower muscle mass and risk factor for T2DM NHPs.
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