Related Experiment Video

Updated: Aug 13, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.3K

Human Mastadenovirus A Infection in a Child During the Course of Hematopoietic Stem Cell Transplant

Siddika Songul Yalcin1, B Baris Kuskonmaz, Vicente Perez-Brocal

  • 1From the Department of Social Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|January 19, 2023
PubMed

Insights

Human mastadenovirus reactivation can complicate recovery after allogeneic hematopoietic stem cell transplant in pediatric patients. Continued monitoring is crucial for understanding virus persistence and latency post-transplant.

Area of Science:

  • Virology
  • Immunology
  • Hematology

Background:

  • Human mastadenoviruses are known to persist in various tissues post-primary infection.
  • Allogeneic hematopoietic stem cell transplantation (HSCT) is a complex procedure with potential complications.
  • Pediatric patients with Fanconi anemia are particularly vulnerable post-HSCT.

Observation:

  • A pediatric patient with Fanconi anemia experienced a complicated post-HSCT course.
  • Metagenomic analysis revealed human mastadenovirus reactivation during the 3-month follow-up period.
  • High viral loads were detected at day +15 (84%) and day +30 (90%), with shedding continuing for 3 months.

Findings:

  • Human mastadenovirus reactivation occurred in a pediatric HSCT recipient.
  • The virus demonstrated significant replication and shedding in the post-transplant period.
  • The patient achieved full donor chimerism and good clinical condition at 36 months post-HSCT.

Implications:

  • This case highlights the importance of monitoring for human mastadenovirus reactivation in HSCT recipients.
  • Further long-term follow-up studies are necessary to elucidate the latency patterns of human mastadenoviruses.
  • Understanding viral persistence is key to improving outcomes for immunocompromised patients.

More Related Videos

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System10:24

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Published on: October 5, 2015

12.5K
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.8K

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
386
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.1K