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Related Experiment Videos

Hypersomnolence with beta-adrenergic blockers.

J Thachil1, J R Zeller, M S Kochar

  • 1Hypertension Section, Zablocki Veterans Administration Medical Center, Milwaukee 53295.

Chest
|November 1, 1987
PubMed
Summary

Beta-adrenergic blocking agents like propranolol and atenolol can cause hypersomnolence, a recognized side effect. Switching to captopril resolved the issue in an elderly patient.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Geriatrics

Background:

  • Beta-adrenergic blocking agents are widely used for cardiovascular conditions.
  • Propranolol (lipophilic) and atenolol (hydrophilic) are common examples.
  • Neuropsychiatric side effects of these drugs are documented, but hypersomnolence is less recognized.

Observation:

  • An elderly male patient with hypertension and mild dementia developed hypersomnolence while taking propranolol.
  • Hypersomnolence persisted with atenolol and resolved upon its discontinuation.
  • Re-administration of low-dose beta-blockers induced hypersomnolence again.

Findings:

  • Hypersomnolence was directly linked to beta-adrenergic blocking agents in this patient.
  • Both lipophilic (propranolol) and hydrophilic (atenolol) beta-blockers induced the side effect.
  • Captopril effectively managed hypertension and resolved hypersomnolence.

Implications:

  • Hypersomnolence should be considered a potential side effect of beta-adrenergic blocking agents.
  • This case highlights the importance of thorough medication review for unexplained symptoms.
  • Alternative antihypertensives may be necessary for patients experiencing beta-blocker-induced hypersomnolence.

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