Related Experiment Video
Updated: Aug 13, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
Published on: May 2, 2025
Myeloid Maturity: ATRA to Enhance Anti-PD-1?
Daniel J Olson1, Jason J Luke2
1University of Chicago Comprehensive Cancer Center, Chicago, Illinois.
Abstract:
Myeloid-derived suppressor cells (MDSC) are associated with resistance to anti-PD-1 therapies. All-trans retinoic acid (ATRA) may induce maturation of MDSCs and alter their immunosuppressive effects. Adding ATRA to pembrolizumab may target this resistance mechanism to enhance the overall impact of anti-PD-1-based immunotherapy. See related article by Tobin et al., p. 1209.
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