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Updated: Aug 13, 2025
Working with Human Tissues for Translational Cancer Research
Published on: November 26, 2015
Place conditioning in humans: opportunities for translational research
Seetha Krishnan1, Rick A Bevins2, Harriet de Wit3
1Department of Neurobiology and Institute for Neuroscience, University of Chicago, Chicago, IL, 60637, USA.
Rationale:
Translational research, especially research that bridges studies with humans and nonhuman species, is critical to advancing our understanding of human disorders such as addiction. This advancement requires reliable and rigorous models to study the underlying constructs contributing to the maladaptive behavior.
Objective:
In this commentary, we address some of the challenges of conducting translational research by examining a single procedure, place conditioning. Place conditioning is commonly used with laboratory animals to study the conditioned rewarding effects of drugs, and recent studies indicate that a similar procedure can be used in humans.
Results:
We discuss the opportunities and challenges of making the procedure comparable across species, as well as discuss the benefits of more systematically applying the procedure to humans.
Conclusion:
We argue that the capacity of humans to report verbally on their internal experiences (perceptions, affective states, likes and dislikes) add an important dimension to the understanding of the procedures used in laboratory animals.
