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Age-related alterations in retinal function.

L R Trick1

  • 1School of Optometry, University of Missouri-St. Louis 63121.

Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1987
PubMed
Summary

Healthy aging can impact vision due to neurophysiological changes in the retina. This study found significant age-related alterations in retinal processing (PERG) and cortical processing (VECP) in older adults.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Gerontology

Background:

  • Age-related visual deficits are common, even without disease.
  • Optical factors are understood, but neurophysiological changes are less clear.

Purpose of the Study:

  • To investigate age-related changes in retinal and cortical visual processing.
  • To differentiate between optical and neurophysiological contributions to age-related vision loss.

Main Methods:

  • Recorded pattern electroretinograms (PERG) and visual evoked cortical potentials (VECP) in young and elderly adults.
  • Used modulated checkerboard patterns to assess visual processing.
  • Ensured all participants had good corrected visual acuity.

Main Results:

  • Significant age-related differences in waveform amplitude and latency were found for both PERG and VECP.
  • Cortical potential changes were partly explained by reduced retinal illumination (senile miosis).
  • Retinal potential alterations were not fully explained by reduced illumination, suggesting intrinsic retinal changes.

Conclusions:

  • Neurophysiological changes within the retina likely contribute to visual deficits in healthy aging.
  • Age-related visual decline may stem from alterations in neural processing at the retinal level.

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