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Related Experiment Videos

Contrast sensitivity and pattern visual evoked potential in patients with glaucoma.

H Abe1, S Hasegawa, K Iwata

  • 1Department of Ophthalmology, Niigata University School of Medicine, Japan.

Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1987
PubMed
Summary

Contrast sensitivity and pattern visual evoked potential (VEP) can monitor glaucoma progression. However, these tests are less sensitive than visual field measurements for detecting early optic nerve damage in glaucoma.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Optometry

Background:

  • Glaucoma is a progressive optic neuropathy often associated with elevated intraocular pressure.
  • Early detection and monitoring of glaucomatous optic nerve damage are crucial for preserving vision.

Purpose of the Study:

  • To evaluate the efficacy of contrast sensitivity and pattern visual evoked potential (VEP) in detecting and monitoring glaucomatous optic nerve damage at various disease stages.
  • To compare the sensitivity of contrast sensitivity and pattern VEP with established diagnostic methods like visual field testing and fundus photography.

Main Methods:

  • Contrast sensitivity and pattern VEP were measured in patients with ocular hypertension and primary open-angle glaucoma.
  • Quantitative visual field examination, retinal nerve fiber layer assessment, and optic disc evaluation using magnified stereoscope fundus photography were performed.

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Main Results:

  • Contrast sensitivity remained within normal limits in the early stages of glaucoma, progressing to high/low-frequency loss and then a level type of loss with advanced optic nerve damage.
  • Pattern VEPs demonstrated increasing abnormalities correlating with the progression of glaucomatous optic nerve damage.
  • Contrast sensitivity and pattern VEP were less sensitive than visual field measurements and fundus photography for detecting minor optic nerve damage in early glaucoma.

Conclusions:

  • Contrast sensitivity and pattern VEP may not be sufficiently sensitive for the initial diagnosis of early glaucoma.
  • These electrophysiological and psychophysical tests can serve as valuable objective and subjective tools for monitoring the progression of optic nerve damage in established glaucoma cases.