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miR-124-3p mediates polygenic risk shared between schizophrenia and bipolar disorder
Dariusz Żurawek1, Gustavo Turecki1
1Department of Psychiatry, Douglas Institute, McGill University, 6875 LaSalle Boulevard, Montreal, QC H4H 1R3, Canada.
Neuron
|January 19, 2023
Summary
The microRNA miR-124-3p links schizophrenia and bipolar disorder by influencing shared genetic risk factors. This microRNA contributes to behavioral changes common in both disorders via AMPA receptor pathways.
Area of Science:
- Neuroscience
- Genetics
- Molecular Biology
Background:
- Schizophrenia and bipolar disorder share genetic risk factors and behavioral symptoms.
- MicroRNAs play crucial roles in regulating gene expression and neuronal function.
Purpose of the Study:
- To investigate the role of microRNA miR-124-3p in the shared pathophysiology of schizophrenia and bipolar disorder.
- To determine how miR-124-3p influences behavioral alterations and neurotransmission in these disorders.
Main Methods:
- Analysis of polygenic risk scores shared between schizophrenia and bipolar disorder.
- Assessment of miR-124-3p association with these risk scores.
- Investigation of miR-124-3p's effect on AMPA receptor neurotransmission and associated behaviors.
Main Results:
- miR-124-3p is associated with polygenic risk scores common to schizophrenia and bipolar disorder.
- This microRNA confers risk to behavioral alterations observed in both disorders.
- Modulation of AMPA receptor neurotransmission by miR-124-3p underlies these behavioral effects.
Conclusions:
- miR-124-3p serves as a molecular link between shared genetic risks and behavioral phenotypes in schizophrenia and bipolar disorder.
- Targeting miR-124-3p or AMPA receptor pathways may offer therapeutic strategies for both conditions.
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