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aGABRacadabra: A surprising new role for GABAA receptors in cortical development

Nazim Kourdougli1, Carlos Portera-Cailliau2

  • 1Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA.

Neuron
|January 19, 2023
PubMed

Abstract:

In this issue of Neuron, Babij, Ferrer, and colleagues provide new evidence that β3 subunit of GABAA receptors is critical for the maturation of functional networks in the neonatal somatosensory cortex.

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
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