The error minimization of the genetic code would have been determined by natural selection and not by a neutral...

I discuss the mechanisms by which the error minimization observed in the genetic code would have been produced; that is, the ability of the genetic code to buffer, for example, the deleterious effects of translation errors. Here, I analyse whether the error minimization was produced by the intervention of natural selection or whether it is an emergent, that is, neutral property; in other words, whether it is a by-product of another mechanism that was structuring the genetic code. In particular, I criticize Massey's simulations (2008) - favouring the neutral hypothesis - which, containing elements of natural selection, would render his conclusions at least partly tautological. Furthermore, I criticize some of Koonin's (2017) interpretations regarding Massey's simulations. Finally, I criticize the opinion of Janzen et al. (2022) according to which their self-aminoacylating ribozyme system would have been capable of generating an error minimization of the genetic code as its emergent property. That is to say, I criticize, more generally, a neutral origin of error minimization. Indeed, any mechanism for structuring the genetic code would be capable of generating, in theory, such an emergent property. The problem is that to demonstrate this, it would be necessary to show that the level of optimization achieved by the genetic code would be that expected under the neutral hypothesis, the one that Janzen et al. (2022) instead they did not make. Therefore, their view is only a hypothesis and is very far from being corroborated by their results. Instead, in the literature there is a strong evidence that the level of optimization achieved by the genetic code is so high that it would imply, per se, an intervention of natural selection in the origin of error minimization of the genetic code. On the other hand, this level of optimization would be very far from what might have been produced by a neutral process.