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microRNA as a therapeutic for ischemic stroke
Raluca Todoran1, Sarina R Falcione2, Michael Clarke3
1Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Neurochemistry International
|January 19, 2023
Summary
microRNAs (miRNA) show promise as a novel stroke treatment by targeting thrombosis, inflammation, and blood-brain barrier disruption. Further research is needed to advance miRNA therapies from animal studies to human clinical applications for ischemic stroke.
Area of Science:
- Biomedical Science
- Molecular Biology
- Neuroscience
Background:
- microRNAs (miRNA) are key regulators of gene expression with therapeutic potential.
- Ischemic stroke involves complex cellular and molecular pathways that can be modulated by miRNA.
- Current stroke treatments have limitations, creating a need for novel therapeutic strategies.
Conclusions:
- miRNA represent a promising, emerging therapeutic strategy for ischemic stroke.
- Addressing barriers and advancing research are crucial for translating miRNA potential into clinical practice.
- Future research should focus on optimizing delivery, specificity, and safety for miRNA-based stroke therapies.
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