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Updated: Aug 13, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
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Clinical Symptoms Affect Treatment and Prognosis in Pediatric Patients with Congenital Pulmonary Airway Malformation:

Guowei Zeng1, Qi Zhang1, Binqian Song1

  • 1Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.

Journal of Pediatric Surgery
|January 19, 2023
PubMed

Insights

Surgery for congenital pulmonary airway malformation (CPAM) is safer before symptoms appear. Key factors like age, diagnosis timing, and cyst size influence symptom development in CPAM patients.

Area of Science:

  • Pediatric Surgery
  • Thoracic Surgery
  • Congenital Malformations

Background:

  • Congenital pulmonary airway malformation (CPAM) management, particularly for asymptomatic cases, remains a subject of debate.
  • Understanding factors that precipitate symptoms is crucial for timely intervention.

Purpose of the Study:

  • To evaluate the safety and efficacy of surgical intervention in asymptomatic CPAM patients.
  • To identify predictors of symptom development in individuals with CPAM.

Main Methods:

  • A retrospective analysis of a CPAM patient database.
  • Propensity score matching (PSM) to compare perioperative outcomes between symptomatic and asymptomatic groups.
  • Multivariable logistic regression to identify factors associated with symptomatic lesions.

Main Results:

  • Asymptomatic CPAM patients demonstrated significantly better perioperative outcomes, including shorter operating times, reduced need for mechanical ventilation, shorter chest tube duration, and decreased hospital stays.
  • No significant differences were observed in thoracotomy conversion rates or postoperative complications between the matched groups.
  • Age, postnatal diagnosis, and maximum cyst diameter were independently associated with the development of symptoms.

Conclusions:

  • Surgical intervention for CPAM appears to yield superior perioperative results when performed before symptom onset.
  • Age at diagnosis, method of diagnosis (postnatal), and the maximum diameter of the cyst are significant predictors of symptomatic presentation in CPAM.
Abstract

Keywords:
ChildrenCongenital pulmonary airway malformationSurgeryThoracoscopy

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