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Updated: Aug 13, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Ligand-accelerated, branch-selective oxidative cyanation of alkenes
Jun Yang1, Huan Li1, Jian Qin1
1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Center for Advanced Low-Dimension Materials, Donghua University, Shanghai 201620, China.
Abstract:
A ligand-accelerated, branch-selective oxidative cyanation of alkenes has been developed in the presence of catalytic Cu2O. Both styrenes and aliphatic alkenes with directing groups are well tolerated in this inexpensive protocol. The mild condition allows for a good tolerance of functional groups, enabling facile access to a diverse array of simple and complex branched vinyl nitriles. The wide synthetic utility of this methodology has been further demonstrated via the efficient scaleup in both batch and continuous flow processes.
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