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Updated: Aug 13, 2025

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The Burden of Sickle Cell Disease in Saudi Arabia: A Single-Institution Large Retrospective Study
Amerah Bin Zuair1, Sheikhah Aldossari1, Rand Alhumaidi1
1Department of Internal Medicine, College of Medicine, King Saud University and King Saud University Medical City, Riyadh, Saudi Arabia.
Insights
Sickle cell disease (SCD) patients experience frequent hospital admissions and high readmission rates, impacting quality of life and healthcare costs. Specialized multidisciplinary clinics are recommended to manage SCD effectively.
Area of Science:
- Internal Medicine
- Hematology
- Public Health
Background:
- Sickle cell disease (SCD) presents a substantial challenge to patients and healthcare systems.
- High readmission rates are a significant factor contributing to the burden of SCD.
Purpose of the Study:
- To characterize adult SCD patients admitted to General Internal Medicine.
- To determine the etiology of admissions, annual admission rates, length of stay, and readmission rates for SCD patients.
Main Methods:
- Retrospective observational study design.
- Inclusion of all adult SCD patients admitted to the General Internal Medicine (GIM) unit from 2016 to 2021.
Main Results:
- 160 adult SCD patients were analyzed (mean age 31.08 years, 51.25% female).
- Average annual emergency department (ED) visits were 4, with 19% having ≥3 admissions.
- Mean length of stay was 6 days; 30-day readmission rate was 24.5%.
Conclusions:
- SCD imposes a significant economic and healthcare burden in Saudi Arabia.
- High ED visits, readmission rates, and prolonged hospitalizations highlight the need for improved care.
- Implementation of specialized sickle cell disease multidisciplinary clinics is advocated.
Purpose:
Sickle cell disease (SCD) is a significant burden for patients and healthcare systems due to multiple factors, including high readmission rates. This study aimed to determine the general characteristics, etiology of admissions, annual admission rate, length of stay, and readmission rate of patients with SCD.
Patients And Methods:
This retrospective observational study included all adult patients with SCD admitted to the General Internal Medicine (GIM) unit between 2016 and 2021.
Results:
There were 160 patients (mean age, 31.08 ± 9.06 years; 51.25% female) with SCD included in this study. Most originated from southern Saudi Arabia (45.62%). The average annual number of emergency department (ED) visits was 4, and approximately 19% of patients had ≥3 annual admissions. The mean length of stay was 6 days. The readmission rates at 7, 30, 60, and 90 days were 8%, 24.5%, 13.6%, and 10.8%, respectively.
Conclusion:
SCD generates a significant economic burden on the Saudi society and the effects on the healthcare system and patients' quality of life are evident in the high ED visits, readmission rates and prolonged hospitalization. Thereupon we advocate the implementation of sickle cell disease-specialized multidisciplinary clinics.
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