Related Experiment Video
Updated: Aug 13, 2025

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
Published on: December 3, 2016
Metaphyseal chondroblastoma in a pediatric patient
Mauricio Paradeda Chiesa1, Breanna M Thompson2, Natalia Maciel1
1Unidad de Patología Oncológica Musculo Esquelética, Instituto Nacional de Ortopedia y Traumatología, Luis Alberto de Herrera 2226, Montevideo, Uruguay.
Abstract:
Chondroblastoma is a rare, benign neoplasm usually located in the epiphyses and apophyses of the long bones in the immature skeleton. Radiologically, these tumors have a classic appearance of a lytic lesion with chondroid matrix surrounded by a thin sclerotic rim. Here, we describe the case of a 5-year-old male who presented with a chondroblastoma unusually located exclusively in the metaphyseal region, which led to an elusive diagnosis. The presence of tumors outlying the traditional location or epidemiological spectrum, along with the potential for histopathological misdiagnosis, can pose a diagnostic and therapeutic challenge for the treating team.
Related Concept Videos
Bone Formation by Endochondral Ossification
Growth of Cartilage and Bone Tissue
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

