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Updated: Aug 13, 2025
A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
Published on: September 11, 2020
Research hotspots and development trends of microRNA in ischemia-reperfusion: network analysis of academic journals
Yang-Li He1, Ya-Li Yang1, Wen-Xing Xu1
1Center of Geriatrics, Hainan Clinical Research Center for Cardiovascular Disease, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
Background:
Ischemia-reperfusion (IR) injury can occur in the heart, brain, liver, lung, kidney, and other important organs, and may greatly increase disease mortality. MicroRNAs (miRNAs) have a variety of functions, including regulating cell differentiation, proliferation, and apoptosis. In the past 10 years, many studies on miRNAs in IR have been conducted. This study involved a visual analysis of these studies, and a discussion of research hotspots, trends, and frontiers of this topic.
Methods:
A total of 1,518 articles published between 2012 and 2022 on the topic of miRNA and IR and listed in the Web of Science database were analyzed visually using CiteSpace. Cooperative networks, literature citations, and keyword co-occurrence were analyzed.
Results:
Of the 1,518 articles, most were published after 2018, and a rapid growth in numbers of publications was seen after 2019. Articles from China numbered the highest, followed by the United States and Canada. It has been found that many miRNAs are involved in the occurrence of IR, with various regulatory mechanisms and signaling pathways. The literature clustering generated by literature co-citation analysis and the keyword co-occurrence network showed that the previous miRNA research on IR had mainly focused on the following topics: myocardial infarction, ischemic stroke, acute kidney injury, oxidative stress, and inflammatory response. More attention has been paid to long noncoding RNA (lncRNA) and exosomes, with much exploration having been conducted in these areas.
Conclusions:
Although miRNA is involved in the occurrence and development of IR, as a clinical intervention target for IR, further research is still needed.
Insights
MicroRNAs (miRNAs) are key regulators in ischemia-reperfusion (IR) injury across organs. While research is rapidly growing, further investigation is needed to explore miRNAs as clinical targets for IR.
Area of Science:
- Biomedical Sciences
- Molecular Biology
- Genetics
Background:
- Ischemia-reperfusion (IR) injury affects multiple organs and increases mortality.
- MicroRNAs (miRNAs) regulate crucial cellular processes like differentiation, proliferation, and apoptosis.
- Extensive research has focused on the role of miRNAs in IR over the past decade.
Purpose of the Study:
- To conduct a visual analysis of studies on miRNAs in IR.
- To identify research hotspots, trends, and frontiers in miRNA and IR research.
Main Methods:
- A bibliometric analysis of 1,518 articles published between 2012 and 2022 was performed.
- Data was sourced from the Web of Science database.
- CiteSpace software was used for visual analysis, including cooperative network, citation, and keyword co-occurrence analysis.
Main Results:
- Publication numbers show rapid growth, particularly after 2019, with China, the US, and Canada leading in contributions.
- Key research areas include myocardial infarction, ischemic stroke, acute kidney injury, oxidative stress, and inflammatory responses.
- Emerging trends highlight the significance of long noncoding RNAs (lncRNAs) and exosomes in IR research.
Conclusions:
- MicroRNAs play a significant role in the occurrence and development of IR.
- Despite the established involvement of miRNAs, their potential as clinical intervention targets for IR requires further in-depth research.
