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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
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EccDNA-oriented ITGB7 expression in breast cancer
Lin Yang1, Meixue Wang1, Xi'e Hu1
1Department of General Surgery, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Annals of Translational Medicine
|January 20, 2023
Summary
Extrachromosomal circular DNA (eccDNA) in breast cancer (BC) was investigated. The gene ITGB7, identified on eccDNA, is upregulated in BC and may serve as a prognostic marker for personalized treatment.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Extrachromosomal circular DNA (eccDNA) is prevalent in cancers and linked to tumor progression.
- The specific role of eccDNA in breast cancer (BC) remains largely undetermined.
Purpose of the Study:
- To investigate the function of eccDNA in breast cancer.
- To identify potential biomarkers for BC prognosis and treatment.
Main Methods:
- eccDNA was detected and analyzed using CLeavage Effects by Circularization for In vitro Reporting of sequencing (CECRIS) in a BC tissue sample.
- Bioinformatic analyses, including gene ontology and pathway enrichment, were performed on detected eccDNA genes.
- Public databases (GTEx, TCGA) were utilized to correlate eccDNA gene expression with BC patient data and survival outcomes.
Main Results:
- A total of 200 eccDNA genes were identified, with ITGB7 being notably enriched.
- Enrichment analysis revealed ITGB7's involvement in cell-matrix adhesion, focal adhesion, and the PI3K-Akt signaling pathway.
- ITGB7 was found to be significantly upregulated in BC patients and associated with menopausal status.
Conclusions:
- ITGB7, identified on eccDNA, shows potential as a prognostic biomarker for breast cancer.
- Targeting ITGB7 may offer new avenues for individualized clinical treatment strategies in BC.
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