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Selective uptake by Purkinje neurons of antibodies to S-100 protein
1Department of Psychiatry, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
Forty-eight hours after intraventricular injection, affinity-purified antibodies to S-100 protein localized in Purkinje cells whereas affinity-purified antibodies to goat immunoglobulin or to bovine serum albumin did not. This selective up-take may account for the susceptibility of some neurons to immunologic insult, and may provide further evidence to support hypotheses which invoke autoimmune mechanisms in the pathogenesis of central nervous system disorders.
Forty-eight hours after intraventricular injection, affinity-purified antibodies to S-100 protein localized in Purkinje cells whereas affinity-purified antibodies to goat immunoglobulin or to bovine serum albumin did not. This selective up-take may account for the susceptibility of some neurons to immunologic insult, and may provide further evidence to support hypotheses which invoke autoimmune mechanisms in the pathogenesis of central nervous system disorders.