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Updated: Aug 13, 2025

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Update on classification of oncocytic neoplasms of the kidney
André Oszwald1, Gabriel Wasinger1, Lucia Zisser2
1Department of Pathology.
Purpose Of Review:
This review provides a summary of recent developments in classification of renal oncocytic neoplasms that were incorporated in the fifth edition WHO classification of renal tumors, released in 2022.
Recent Findings:
Besides the distinct entities of renal oncocytoma and chromophobe renal cell carcinoma, the WHO now acknowledges a heterogeneous group of oncocytic tumors of the kidney that can be reported as 'oncocytic renal neoplasms of low malignant potential'. Case series by multiple institutions have revealed recurrent patterns of morphological features, protein marker expression, and genetic alterations within these neoplasms that may permit further subclassification in the future.
Summary:
The new classification system provides pathologists with the opportunity to simplify the diagnostic workup and reporting of morphologically equivocal oncocytic neoplasms.
Insights
The 2022 WHO classification simplifies diagnosing kidney oncocytic tumors. New categories aid pathologists in distinguishing these renal neoplasms, improving diagnostic accuracy.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Renal oncocytic neoplasms encompass a spectrum of tumors with varying malignant potential.
- Accurate classification is crucial for patient management and prognosis.
Conclusions:
- The updated classification offers a streamlined approach for pathologists diagnosing oncocytic renal neoplasms.
- It facilitates improved diagnostic workup and reporting of morphologically ambiguous cases.
- Future research may enable more precise subclassification within this tumor group.
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