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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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Epigenetic-Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer

Chandrima Das1,2, Swagata Adhikari1,2, Apoorva Bhattacharya1

  • 1Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata, India.

Cancer Research
|January 20, 2023
PubMed

Insights

Cancer cells develop drug resistance by altering their metabolism and DNA repair. Understanding the interplay between epigenetics, metabolism, and DNA repair offers new therapeutic strategies for breast cancer.

Area of Science:

  • Oncology
  • Cancer Biology
  • Metabolic Pathways

Background:

  • Therapy resistance in breast cancer is a significant clinical challenge.
  • Reprogramming of energy metabolism is a key, heterogeneous regulator of drug resistance.
  • Metabolic heterogeneity is linked to altered signaling networks and DNA damage response pathways.

Purpose of the Study:

  • To investigate how cancer cell metabolism influences DNA damage repair.
  • To explore the role of metabolic reprogramming in the development of therapy resistance.
  • To identify mechanisms underlying the epigenetics-metabolism-DNA repair axis in cancer.

Main Methods:

  • Analysis of metabolic pathways in cancer cells.
  • Investigation of DNA damage response mechanisms.
  • Exploration of epigenetic regulators' role in metabolic remodeling.

Main Results:

  • Cancer cell metabolic reprogramming is intricately linked to DNA damage repair.
  • Epigenetic regulators remodel the metabolic landscape, impacting genomic stability.
  • The epigenetics-metabolism-DNA repair axis contributes to therapy resistance.

Conclusions:

  • Targeting the epigenetics-metabolism-DNA repair axis may overcome therapy resistance.
  • Novel therapeutic strategies can sensitize cancer cells to conventional treatments.
  • Understanding metabolic heterogeneity is crucial for effective breast cancer management.

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