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Updated: Aug 13, 2025

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Orbital Involvement in Multiple Myeloma.

Marissa K Shoji1, Ying Chen, Nicole J Topilow

  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida, U.S.A.

Ophthalmic Plastic and Reconstructive Surgery
|January 20, 2023
PubMed
Summary

Orbital multiple myeloma (MM) presents with proptosis and diplopia, often as the first sign of systemic disease. While treatments like chemoradiation can improve orbital symptoms, the overall prognosis for orbital MM remains poor.

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Area of Science:

  • Ophthalmology
  • Hematology
  • Oncology

Background:

  • Multiple myeloma (MM) can involve the orbit, impacting vision and ocular structures.
  • Characterizing orbital MM is crucial for early diagnosis and management due to its poor prognosis.

Approach:

  • A retrospective chart review of 7 patients with orbital MM was conducted.
  • A comprehensive PubMed literature review identified 111 additional cases of orbital MM.

Key Points:

  • Orbital lesions in MM are often unilateral, superolateral, and can infiltrate extraocular muscles or lacrimal glands.
  • Orbital MM may be the initial presentation of systemic disease in nearly half of cases.
  • Chemoradiation and chemotherapy are common treatment modalities, offering potential improvement in orbital disease.

Conclusions:

  • Orbital MM requires prompt recognition for improved patient outcomes.
  • Despite treatment, orbital MM carries a poor overall prognosis, emphasizing the need for further research.