[Effect of intracisternal administration of antisera against neurospecific enolase (protein 14-3-2) on avoidance...

The antisera to three isoenzymes (alpha alpha, alpha gamma, and gamma gamma) of the rat neurospecific enolase were studied. gamma gamma-antiserum administered into the brain cistern (8 microliters) prior to learning, in contrast to two other antisera, impaired the retrieval of passive avoidance response within 1-28 days after learning. Maximal amnestic effect occurred in the first 3 days. Probable mechanisms of the neurospecific enolase participation in the formation of memory traces, are discussed.