Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

208
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
208
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

190
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
190
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.5K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.5K
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

205
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
205

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluid-Thermal-Structure Coupled Analysis on the Tempering Characteristics of Glassware During Air Cooling.

Materials (Basel, Switzerland)·2026
Same author

Unveiling the pharmacological basis of Rhodiola crenulata for atopic dermatitis: A multi-model approach combining zebrafish, mouse studies, and intelligent computational analysis.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Hexokinase 2 upregulation is associated with glycolytic reprogramming and neuroinflammation in hypoxic-ischemic brain damage: a therapeutic target for early intervention.

Frontiers in immunology·2026
Same author

CMA-DTI: a cross-modal fusion and attentive interaction network for interpretable drug-target interaction prediction.

Frontiers in bioinformatics·2026
Same author

Apelin-13 ameliorates hypoxic-ischemic brain damage and improves neurological function in neonatal rats by attenuating neuroinflammation via AMPK activation.

International immunopharmacology·2026
Same author

EXPRESS: Activation of GPR17 ameliorates neuroinflammation and improves neurological function via NF-κB pathway in an experimental germinal matrix hemorrhage rat model.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026

Related Experiment Video

Updated: Aug 13, 2025

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.4K

Impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction.

Jiuqi Wang1,2, Yiming Tian1,2, Chi Qin1,2

  • 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Journal of Neurology
|January 20, 2023
PubMed
Summary

Obstructive sleep apnea (OSA) impairs cognitive function by affecting the brain's glymphatic drainage system. CPAP treatment can improve this drainage and potentially cognitive decline.

Keywords:
Cognitive impairmentDynamic contrast-enhanced magnetic resonance imagingGlymphaticObstructive sleep apnea

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

762
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K

Related Experiment Videos

Last Updated: Aug 13, 2025

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.4K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

762
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K

Area of Science:

  • Neuroscience
  • Radiology
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) is common and linked to cognitive impairment.
  • The exact mechanisms connecting OSA and cognitive decline are not fully understood.
  • Morphological changes in perivascular spaces (PVSs) are observed in OSA patients.

Purpose of the Study:

  • To investigate the relationship between OSA, PVSs, and cognitive impairment.
  • To evaluate the glymphatic drainage system's fluid dynamics in OSA patients using novel DCE-MRI techniques.
  • To assess the impact of CPAP treatment on glymphatic function and cognitive status in OSA.

Main Methods:

  • Utilized novel dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) methods.
  • Assessed fluid dynamics of the glymphatic drainage system, including inflow and outflow parameters.
  • Correlated glymphatic parameters with cognitive function, hypoxia levels, and PVS morphology in OSA patients.

Main Results:

  • OSA patients exhibited altered glymphatic inflow and outflow parameters, indicating impaired drainage.
  • Impaired glymphatic outflow correlated with the severity of cognitive impairment and hypoxia.
  • One month of CPAP treatment improved glymphatic drainage system performance in OSA patients.

Conclusions:

  • OSA-induced chronic intermittent hypoxia impairs glymphatic drainage, contributing to cognitive decline.
  • Ventilation improvement via CPAP may be a therapeutic strategy for OSA-related cognitive impairment.
  • Morphological changes in PVSs and altered glymphatic function are key factors in OSA-associated cognitive deficits.