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Urinary stone disease in Syrian children
Mohamad Klib1, Munir Ghandour2, Hala Wannous3
1Faculty of Medicine, Damascus University, Damascus, Syria. MohamadKlib98@gmail.com.
Pediatric Nephrology (Berlin, Germany)
|January 20, 2023
Summary
Pediatric urinary stone disease (USD) is common, with metabolic disorders and anatomical issues being frequent causes. Rare causes of pediatric USD increase the risk of severe complications like acute kidney injury (AKI) and chronic kidney disease (CKD).
Area of Science:
- Pediatric Nephrology
- Urology
- Medical Genetics
Background:
- Pediatric urinary stone disease (USD) represents a significant healthcare burden.
- Understanding the diverse etiologies of pediatric USD is crucial for effective management.
Purpose of the Study:
- To investigate the clinical characteristics and outcomes of pediatric USD.
- To differentiate between common and rare causes of USD in children.
- To identify risk factors and complications associated with different USD etiologies.
Main Methods:
- A retrospective descriptive cohort study was conducted.
- Included children under 13 years with confirmed USD from January 2013 to December 2019.
- Patients were categorized into common and rare causes groups based on etiology.
Main Results:
- The study analyzed 235 pediatric patients with USD.
- Common causes included metabolic disorders (45.5%) and anatomical abnormalities (22.3%).
- Rare causes included uric acid stones (37.5%), cystinuria (21.9%), and primary hyperoxaluria (15.6%).
- Patients with rare causes had a higher incidence of AKI, CKD, bilateral, and recurrent stones (P < 0.05).
- Calcium oxalate (34.9%) and uric acid (14.4%) were the predominant stone types.
Conclusions:
- Rare causes of pediatric USD are associated with increased risk of severe complications.
- Early diagnosis and management are essential for children with rare USD etiologies.
- The high prevalence of uric acid stones warrants further investigation into underlying causes.
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