Sr2+ may differentiate high and low affinity Ca2+ stores in guinea-pig trachealis
1Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505.
General Pharmacology
|January 1, 1987
Abstract:
1. In guinea-pig trachealis Ca2+ are mobilized from different stores to produce the contractions to various agents. 2. Sr2+ can substitute for Ca2+ and maintain responses to KC1 but not responses to A23187 or agents acting via drug-receptor interaction. 3. Resting tone and responses to KC1 are supported by low affinity Ca2+. 4. Responses to the other agents are supported by high affinity Ca2+.
