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Relationship between elevated fibrinopeptide A levels and alpha-2-antiplasmin
F Marongiu1, G Mulas, A M Mamusa
1Istituto di Medicina Interna, Università di Cagliari, Italia.
Haemostasis
|January 1, 1987
Summary
This study explored the link between alpha 2-antiplasmin (alpha 2-AP) and thrombin activity. Findings indicate that elevated thrombin activity, measured by fibrinopeptide A (FPA), is associated with reduced alpha 2-AP levels, suggesting fibrinolysis activation.
Area of Science:
- Biochemistry
- Hematology
- Clinical Medicine
Background:
- Thrombin activity is implicated in various diseases.
- Alpha 2-antiplasmin (alpha 2-AP) is a key inhibitor of plasmin.
- The relationship between thrombin activity and alpha 2-AP consumption requires further elucidation.
Purpose of the Study:
- To investigate the correlation between alpha 2-antiplasmin (alpha 2-AP) levels and thrombin activity.
- To assess if alpha 2-AP levels are affected in patients with conditions linked to heightened thrombin generation.
Main Methods:
- Measured alpha 2-antiplasmin (alpha 2-AP) and fibrinopeptide A (FPA) in 51 patients.
- Patients had atherosclerotic disease, chronic inflammatory disease, or hematological neoplastic disease.
- Analyzed correlations between alpha 2-AP and FPA levels across different patient subgroups.
Main Results:
- A significant negative correlation was observed between alpha 2-AP and FPA (p < 0.01).
- Patients with the highest FPA concentrations (> 9 ng/ml) exhibited significantly reduced alpha 2-AP levels.
- The negative relationship between alpha 2-AP and FPA was most pronounced in the high FPA subgroup.
Conclusions:
- Elevated thrombin activity, indicated by high FPA, is associated with partial consumption of alpha 2-AP.
- This suggests a potential subclinical activation of fibrinolysis secondary to increased thrombin activity in these patient groups.
- The findings highlight a dynamic interplay between coagulation and fibrinolysis markers in disease states.