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Pulmonary diffusion indices in ageing adults.

S Singh1, V Kumar, P Gupta

  • 1Department of Physiology, University College of Medical Sciences, Shahdara, Delhi.

Indian Journal of Physiology and Pharmacology
|January 1, 1987
PubMed
Summary
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This study measured lung transfer factor (Tl) in healthy adults aged 35-70. Males showed a higher Tl (29.41 mlCO/min/mmHg) than females (22.49 mlCO/min/mmHg), with regression analysis exploring influencing factors.

Area of Science:

  • Pulmonary physiology
  • Respiratory medicine

Background:

  • Lung transfer factor (Tl) is a key indicator of gas exchange efficiency.
  • Understanding Tl variations in healthy adults is crucial for interpreting lung function tests.

Purpose of the Study:

  • To measure and compare lung transfer factor (Tl) in healthy adult males and females.
  • To investigate the correlation of Tl with age, height, and hemoglobin levels.

Main Methods:

  • Single breath-holding Carbon Monoxide (CO) technique used for Tl measurement.
  • Study included 147 healthy males and 88 healthy females, aged 35-70 years.
  • Subjects were non-smokers with no reported cardio-respiratory issues.

Main Results:

  • Mean Tl in males was 29.41 ± 1.78 mlCO/min/mmHg.

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  • Mean Tl in females was 22.49 ± 1.28 mlCO/min/mmHg.
  • Regression equations were developed to analyze the relationship between Tl and physiological parameters.

    • Conclusions:

    • Significant differences in lung transfer factor (Tl) exist between healthy adult males and females.
    • Age, height, and hemoglobin levels are potential factors influencing Tl, requiring further regression analysis.