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Related Experiment Video

Updated: Aug 13, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Can Maternal Exposure to Air Pollution Affect Post-Natal Liver Development?

Yong Song¹, Ling Chen^2,3, Ellen Bennett⁴

¹Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, TAS 7001, Australia.

|January 20, 2023

Summary

Maternal exposure to residential particulate matter (PM) during pregnancy did not significantly impact liver metabolism or cellular responses in pups. However, prenatal PM exposure did cause liver genomic DNA damage, varying by PM sample.

Keywords:

genotoxicity liver development maternal exposure particulate matter

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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Area of Science:

Environmental Health
Toxicology
Developmental Biology

Background:

Inhalation of particulate matter (PM) is linked to adverse health outcomes.
Early life stages are particularly susceptible to environmental pollutants.
The impact of prenatal exposure to real-world PM on liver development requires further investigation.

Purpose of the Study:

To investigate the effects of in utero exposure to residential particulate matter (PM) on the developing liver in mice.
To assess impacts on hepatic metabolism, cellular responses, and genotoxicity.

Main Methods:

Pregnant mice were intranasally administered residential PM during mid-late gestation.
Liver tissues from two-week-old pups were analyzed for glycogen, lipids, oxidative stress, inflammation, and fibrosis.
Genomic DNA damage was assessed using various biochemical assays, histological staining, ELISA, and qPCR.

Main Results:

Prenatal PM exposure did not cause significant alterations in hepatic metabolism (glycogen, lipids).
No pronounced effects on cellular responses like oxidative stress, inflammation, or fibrosis were observed.
Evidence of liver genomic DNA damage was detected in pups exposed in utero, with sample-dependent variations.

Conclusions:

In utero exposure to real-world residential PM during mid-late pregnancy has limited impact on post-natal liver development.
Prenatal PM exposure can induce liver genomic DNA damage, highlighting potential long-term risks.
PM sample characteristics may influence the observed genotoxic effects on the developing liver.