Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

2.7K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
2.7K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.1K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.1K
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.5K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Directional motion of a self-steering active intruder in a dense crowd of cognitive active agents.

Scientific reports·2026
Same author

Reversible formation of von-Willebrand-factor-platelet aggregates in microvascular blood flow.

PNAS nexus·2025
Same author

Tunable colloidal swarmalators with hydrodynamic coupling.

Nature communications·2025
Same author

Wrapping of Nano- and Microgels by Lipid-Bilayer Membranes.

ACS macro letters·2025
Same author

Polymeric and Polymer-Functionalized Drug Delivery Vectors: From Molecular Architecture and Elasticity to Cellular Uptake.

Polymers·2025
Same author

Run-and-tumble dynamics of <i>Escherichia coli</i> is governed by its mechanical properties.

Journal of the Royal Society, Interface·2025
Same journal

Formation of Bimetallic Nanoparticles via Exsolution Using a Reducible Metal Oxide Capping Layer.

ACS nano·2026
Same journal

Cold-Driven Thermoelectric Patch for Postoperative Tumor Control.

ACS nano·2026
Same journal

Chemically Fueled Interfacial Supramolecular Polymerization.

ACS nano·2026
Same journal

Tactile Neuromorphic Ion-Gated Vertical Transistor Displays Enabling Dual-Output Reservoir Computing.

ACS nano·2026
Same journal

In Situ Oxygen Shuttling within a Bilayer Electrified Membrane Enables Aeration-Free Electro-Fenton Water Purification.

ACS nano·2026
Same journal

Single Atoms as Growth Directors: From Graphene Edges to Atomically Precise Interfaces in 2D Materials.

ACS nano·2026
See all related articles

Related Experiment Video

Updated: Aug 13, 2025

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles
06:26

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles

Published on: December 7, 2017

11.0K

Membrane-Mediated Interactions Between Nonspherical Elastic Particles.

Jiarul Midya1, Thorsten Auth1, Gerhard Gompper1

  • 1Theoretical Physics of Living Matter, Institute for Biological Information Processing and Institute for Advanced Simulation, Forschungszentrum Jülich, 52425 Jülich, Germany.

ACS Nano
|January 20, 2023
PubMed
Summary
This summary is machine-generated.

Deformable vesicles interacting with lipid membranes show complex wrapping behaviors. Particle softness influences wrapping stability and mediates interactions, impacting applications like drug delivery.

Keywords:
cellular particle uptakecontinuum membrane modelmembrane-mediated interactionspassive endocytosissoft particlesvesicleswrapping

More Related Videos

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

1.9K
Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
09:29

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration

Published on: January 19, 2020

8.5K

Related Experiment Videos

Last Updated: Aug 13, 2025

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles
06:26

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles

Published on: December 7, 2017

11.0K
Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

1.9K
Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
09:29

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration

Published on: January 19, 2020

8.5K

Area of Science:

  • Biophysics
  • Materials Science
  • Cell Biology

Background:

  • Particle transport across lipid membranes is crucial for cellular function.
  • While hard particle wrapping is studied, deformable particle interactions are less understood.
  • Deformable particles include vesicles, viruses, and nanoparticles, relevant in biological and medical contexts.

Purpose of the Study:

  • To investigate the wrapping of nonspherical, deformable vesicles by lipid-bilayer membranes.
  • To predict how vesicle properties (size, shape, elasticity) influence wrapping states.
  • To analyze the interactions between partially wrapped vesicles.

Main Methods:

  • Utilized the Helfrich Hamiltonian for membrane energetics.
  • Employed triangulated membranes for computational modeling.
  • Performed energy minimization to predict vesicle-membrane configurations.

Main Results:

  • Increased vesicle softness stabilizes shallow- and deep-wrapped states over nonwrapped or fully wrapped states.
  • The lipid membrane mediates interactions between partially wrapped vesicles.
  • Deep-wrapped vesicles exhibit repulsion, while shallow-wrapped vesicles show attraction (tip-to-tip) or repulsion (side-by-side).

Conclusions:

  • Vesicle deformability significantly alters wrapping dynamics and inter-vesicle interactions.
  • Understanding these interactions is key for controlling particle assembly at membranes.
  • Findings can inform the design of deformable particles for targeted drug delivery and other medical applications.