MIP-on-a-chip: Artificial receptors on microfluidic platforms for biomedical applications
Tunca Karasu1, Erdoğan Özgür1, Lokman Uzun1
1Department of Chemistry, Faculty of Science, Hacettepe University, Ankara, Turkiye.
Journal of Pharmaceutical and Biomedical Analysis
|January 20, 2023
Summary
Lab-on-a-chip (LOC) technology offers cost-effective, rapid, and sensitive biosensing. This review highlights recent studies on LOC devices combined with molecular imprinting for diverse biomedical applications.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Materials Science
Background:
- Lab-on-a-chip (LOC) integrates laboratory functions onto microfluidic devices.
- Molecularly imprinted biosensing offers selective and sensitive detection.
- LOC and molecular imprinting are promising for point-of-care diagnostics.
Purpose of the Study:
- To review recent studies on microfluidic Lab-on-a-chip devices.
- To highlight the integration of molecular imprinting with LOC technology.
- To discuss their applications in biomedical diagnostics and pharmaceuticals.
Main Methods:
- Review of recent scientific literature.
- Focus on studies combining microfluidics and molecular imprinting.
- Analysis of reported biomedical applications.
Main Results:
- LOC devices offer advantages in cost, speed, sensitivity, and ergonomics.
- Molecularly imprinted LOC platforms enable user- and eco-friendly sensing.
- These integrated systems show potential for on-site and point-of-care measurements.
Conclusions:
- The combination of LOC and molecular imprinting is a powerful approach for biosensing.
- These technologies provide viable alternatives to conventional methods.
- Further research can expand their use in medical diagnostics and drug development.
