Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Aug 13, 2025

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children
05:04

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

Published on: October 4, 2018

7.1K

Pre-frontal stimulation does not reliably increase reward responsiveness.

L M Hadden1, H Penny2, A L Jones3

  • 1Cardiff University, School of Psychology, Tower Building, Park Place, Cardiff, CF10 3AT, UK.

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
|January 20, 2023
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Childhood Exposures to Fluorides and Cognitive Neurodevelopment: A Population-Based Longitudinal Study.

Journal of dental research·2024
Same author

Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study.

Journal of comparative pathology·2020
Same author

An evaluation of methods for the isolation of nontuberculous mycobacteria from patients with cystic fibrosis, bronchiectasis and patients assessed for lung transplantation.

BMC pulmonary medicine·2019
Same author

Microscopic polyangiitis secondary to Mycobacterium abscessus in a patient with bronchiectasis: a case report.

BMC pulmonary medicine·2018
Same author

Public health and the necessary limits of academic freedom?

Vaccine·2016
Same author

Clostridium perfringens type-D enterotoxaemia in cattle: the diagnostic significance of intestinal epsilon toxin.

The Veterinary record·2015
Same journal

The cognitive construction of moral scenes: Associations of visuospatial ability and impulsivity with perspective and vividness in mental simulation.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same journal

Theta band activity during event-file retrieval is influenced by stimulus salience in the preceding action episode.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same journal

Language recovery in Hungarian speakers with aphasia: Roles of phonology and intraindividual variability.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same journal

Neural and behavioral dissociations of self-focused and other-focused incentives in trust.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same journal

A multiverse analysis of the logical memory test and plasma biomarkers of Alzheimer's disease.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same journal

Reading and writing impairments in Spanish-speaking individuals with primary progressive aphasia: A single-case series study.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
See all related articles
This summary is machine-generated.

This study found transcranial magnetic stimulation (TMS) did not increase reward responsiveness in participants, questioning its efficacy for depression treatment. Exploratory analysis indicated active TMS might reduce positive affect.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Depression is a leading cause of global disability, with suicide causing over 800,000 deaths annually.
  • Neuromodulatory treatments like transcranial magnetic stimulation (TMS) are used for depression, despite questions about efficacy and mechanisms.
  • Previous studies suggested excitatory TMS increases reward responsiveness, but replication and dependency on trait reward responsiveness remain unclear.

Purpose of the Study:

  • To replicate Ahn et al.'s (2013) study on TMS and reward responsiveness.
  • To test the reliability of TMS effects and their dependency on trait reward responsiveness, as suggested by Duprat et al. (2016).
  • To investigate the impact of TMS on affect (positive and negative).

Main Methods:

Keywords:
AnhedoniaDepressionReplicationReward responsivenessTranscranial magnetic stimulation

More Related Videos

Pavlovian Conditioned Approach Training in Rats
06:57

Pavlovian Conditioned Approach Training in Rats

Published on: February 4, 2016

11.0K
Studying Food Reward and Motivation in Humans
12:09

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

23.6K

Related Experiment Videos

Last Updated: Aug 13, 2025

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children
05:04

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

Published on: October 4, 2018

7.1K
Pavlovian Conditioned Approach Training in Rats
06:57

Pavlovian Conditioned Approach Training in Rats

Published on: February 4, 2016

11.0K
Studying Food Reward and Motivation in Humans
12:09

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

23.6K
  • Replication of Ahn et al. (2013) using excitatory and sham TMS.
  • Volunteers completed a probabilistic learning task to measure reward responsiveness before and after stimulation.
  • Assessment of positive and negative affect following TMS.

    • Main Results:

    • The probabilistic learning task effectively measured reward responsiveness, irrespective of TMS.
    • This study did not replicate findings that excitatory TMS increases reward responsiveness; evidence favored the null hypothesis.
    • Exploratory analyses indicated that active TMS potentially reduced positive affect.

    Conclusions:

    • The efficacy of TMS for depression treatment is questioned due to a failure to replicate key findings.
    • The potential for active TMS to decrease positive affect warrants caution, especially for individuals with depression.
    • Further research is needed to clarify the biological mechanisms and clinical utility of TMS for depression.