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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Bioinspired microrobots: Opportunities and challenges in targeted cancer therapy
Arun Kumar Singh1, Rajendra Awasthi2, Rishabha Malviya1
1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Abstract:
Chemotherapy is still the most effective technique to treat many forms of cancer. However, it also carries a high risk of side effects. Numerous nanomedicines have been developed to avoid unintended consequences and significant negative effects of conventional therapies. Achieving targeted drug delivery also has several challenges. In this context, the development of microrobots is receiving considerable attention of formulation scientists and clinicians to overcome such challenges. Due to their mobility, microrobots can infiltrate tissues and reach tumor sites more quickly. Different types of microrobots, like custom-made moving bacteria, microengines powered by small bubbles, and hybrid spermbots, can be designed with complex features that are best for precise targeting of a wide range of cancers. In this review, we mainly focus on the idea of how microrobots can quickly target cancer cells and discuss specific advantages of microrobots. A brief summary of the microrobots' drug loading and release behavior is provided in this manuscript. This manuscript will assist clinicians and other medical professionals in diagnosing and treating cancer without surgery.
Insights
Microrobots offer a promising solution for targeted cancer therapy, overcoming chemotherapy side effects and improving drug delivery. These tiny machines can precisely reach tumor sites, enhancing treatment efficacy and aiding in non-surgical cancer management.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Chemotherapy is a primary cancer treatment but has significant side effects.
- Conventional nanomedicines face challenges in targeted drug delivery.
- Microrobots are emerging as a novel solution to overcome these limitations.
Purpose of the Study:
- To review the potential of microrobots for targeted cancer therapy.
- To discuss the advantages of microrobots in drug delivery and cancer treatment.
- To summarize microrobot drug loading and release mechanisms.
Main Methods:
- Review of current microrobot designs (e.g., bacteria-based, microengines, spermbots).
- Analysis of microrobot mobility and tissue infiltration capabilities.
- Examination of drug loading and release strategies for microrobots.
Main Results:
- Microrobots demonstrate enhanced mobility for precise tumor targeting.
- Various microrobot designs offer tailored features for different cancer types.
- Potential for improved drug delivery efficiency and reduced systemic toxicity.
Conclusions:
- Microrobots represent a significant advancement in targeted cancer treatment.
- They offer a promising avenue for overcoming challenges in drug delivery.
- This technology can aid clinicians in non-surgical cancer diagnosis and treatment.
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