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Updated: Aug 13, 2025

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes
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Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes

Published on: September 19, 2013

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MicroRNAs induced by Listeria monocytogenes and their role in cells

Javad Allahverdy1, Niloufar Rashidi1

  • 1Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.

Microbial Pathogenesis
|January 20, 2023
PubMed

Insights

Listeria monocytogenes (Lm) infection impacts pregnancy and vulnerable populations. MicroRNAs (miRNAs) are key to Lm pathogenesis and immune evasion, offering potential therapeutic strategies.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Immunology

Background:

  • Listeria monocytogenes (Lm) is a pathogen causing severe pregnancy complications and neurological issues in vulnerable groups.
  • Lm employs intracellular pathogenesis, manipulating host cell machinery, including nuclear microRNAs (miRNAs).
  • miRNAs are small non-coding RNAs regulating gene expression, crucial for cellular functions and immune responses.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in the context of Listeria monocytogenes infection (listeriosis).
  • To elucidate the mechanisms by which Lm manipulates miRNAs for its survival and immune evasion.
  • To explore the therapeutic potential of miRNAs in combating listeriosis and enhancing host immunity.

Main Methods:

  • Literature review of studies on Listeria monocytogenes pathogenesis.
  • Analysis of research on microRNA regulation and function in host-pathogen interactions.
  • Synthesis of current understanding of miRNA-mediated immune responses in listeriosis.

Main Results:

  • Listeria monocytogenes manipulates host cell microRNAs (miRNAs) to facilitate intracellular survival and evade immune detection.
  • Alterations in miRNA expression significantly impact cellular signaling pathways, particularly those involved in immunity.
  • Dysregulated miRNAs contribute to the pathogenesis of listeriosis.

Conclusions:

  • MicroRNAs (miRNAs) play a critical role in the host-pathogen dynamics of listeriosis.
  • Targeting or utilizing miRNAs presents a promising novel therapeutic avenue for treating Lm infections.
  • Further research into miRNA-based therapies could enhance immune responses against Listeria monocytogenes.
Keywords:
AbortionListeria monocytogenesListeriosismicroRNAmicroRNA therapy

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