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Updated: Aug 13, 2025

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
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Brain nuclear receptors and cardiovascular function.

Mengjie Wang1, Yongjie Yang1, Yong Xu2,3

  • 1Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.

Cell & Bioscience
|January 20, 2023
PubMed
Summary
This summary is machine-generated.

Nuclear receptors (NRs) in the brain significantly impact cardiovascular diseases like hypertension and heart failure. Understanding brain NR signaling offers new therapeutic targets for cardiovascular conditions.

Keywords:
Brain–heart interactionCardiovascular functionCentral nervous systemNuclear receptor

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Area of Science:

  • Neuroscience
  • Cardiology
  • Endocrinology

Background:

  • Growing evidence links brain nuclear receptors (NRs) to cardiovascular disease (CVD) regulation.
  • NRs are widely expressed in the brain and influence key cardiovascular functions.

Purpose of the Study:

  • To review the physiological relevance of brain NRs in cardiovascular function.
  • To discuss neuronal populations responding to brain NRs in cardiovascular control.

Main Methods:

  • Literature review of recent findings on brain NRs and cardiovascular control.
  • Analysis of studies identifying specific neuronal pathways involved.

Main Results:

  • Brain NRs play a crucial role in regulating hypertension, heart failure, and atherosclerosis.
  • Distinct neuronal populations are identified as targets of brain NR signaling in cardiovascular control.

Conclusions:

  • Brain NR signaling is a key mediator of cardiac control and brain dynamics.
  • Targeting brain NRs presents a promising avenue for novel CVD treatments.