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Updated: Aug 13, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Hyperspectral imaging in systemic sclerosis-associated Raynaud phenomenon.

Shannon Teaw¹, Akash Gupta¹, Alyssa Williams¹

¹Section of Rheumatology, Allergy & Immunology, Department of Medicine, Yale School of Medicine, 300 Cedar Street, The Anlyan Center PO Box 208031, New Haven, CT, 06520, USA.

Arthritis Research & Therapy

|January 20, 2023

Summary

Hyperspectral imaging (HSI) offers a feasible method to quantify Raynaud phenomenon (RP) severity in systemic sclerosis (SSc) patients. While HSI shows potential for disease assessment, patient-reported outcomes did not correlate with HSI measurements.

Keywords:

Cochin hand function scale Digital ulcers Hyperspectral imaging Imaging Outcomes Patient-reported outcome instruments Raynaud condition score Raynaud phenomenon Scleroderma Systemic sclerosis

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Area of Science:

Medical Imaging
Rheumatology
Dermatology

Background:

Quantitative outcome measures are lacking for Raynaud phenomenon (RP) clinical trials in systemic sclerosis (SSc).
Hyperspectral imaging (HSI) non-invasively measures skin oxygenation, including oxygenated hemoglobin (oxyHb), deoxygenated hemoglobin (deoxyHb), and oxygen saturation (O2 sat).

Purpose of the Study:

To explore the potential role of HSI in quantifying SSc-RP disease severity and activity.
To assess HSI's feasibility in a clinical setting for SSc-RP patients.

Main Methods:

Prospective recruitment of SSc-RP patients (n=13) and healthy controls (HC; n=12).
Bilateral hand HSI performed at baseline and after a cold provocation challenge (1 min immersion in 15°C water).
Calculation of oxyHb, deoxyHb, and O2 sat values; completion of patient-reported outcome instruments (RCS, CHFS).

Main Results:

SSc patients exhibited higher baseline deoxyHb and lower O2 sat compared to HC (p < 0.05).
SSc patients showed a greater decline in oxyHb and O2 sat post-cold challenge with distinct rewarming trajectories (p < 0.01).
No significant correlations were found between HSI parameters and patient-reported outcome scores (RCS, CHFS).

Conclusions:

HSI is a feasible tool for SSc-RP quantification in a clinical setting.
HSI shows potential as a quantitative measure for SSc-RP severity and activity, particularly in response to cold provocation.
Longitudinal studies are needed to assess HSI's sensitivity to change over time.