Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

869
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
869

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung Ultrasound-Guided Surfactant Therapy in Neonatal Pneumothorax and Pulmonary Hemorrhage: Pathophysiology, Diagnostic Ultrasonography, and Emerging Clinical Approaches.

Children (Basel, Switzerland)·2026
Same author

Neurologic Evaluation of Premature Infants at Term Equivalent Age: Too Early or Too Late? A Scoping Review.

Medicina (Kaunas, Lithuania)·2026
Same author

Mitochondrial Long Non-Coding RNAs in Gynecological Cancers: Pathogenic Signaling Pathways and Therapeutic Opportunities.

Current issues in molecular biology·2026
Same author

Phenotypes of Preterm Birth: A Retrospective Cohort Study from a Tertiary Romanian Centre as a Framework for Future Genomic and Proteomic Research.

Journal of clinical medicine·2026
Same author

Alteration in Fetal Cardiac Function at Mid-Gestation Among Pregnancies Subsequently Complicated by Preeclampsia, Fetal Growth Restriction and Gestational Diabetes Mellitus: A Literature Review.

Journal of clinical medicine·2026
Same author

The Role of Ophthalmic Artery Doppler in Predicting Preeclampsia: A Review of the Literature.

Medicina (Kaunas, Lithuania)·2026

Related Experiment Video

Updated: Aug 13, 2025

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.1K

Gestational Alloimune Liver Disease-Case Report.

Mihaela Demetrian1, Radu Botezatu2, Nicolae Gică2

  • 1Filantropia Clinical Hospital, 011132 Bucharest, Romania.

Children (Basel, Switzerland)
|January 21, 2023
PubMed
Summary

Gestational alloimmune liver disease (GALD) is a rare but severe cause of neonatal acute liver failure. Early treatment with intravenous immunoglobulin (IVIG) may improve outcomes, even if the exact cause is unknown.

Keywords:
acute hepatic failurealloimmune neonatal hepatitisneonatal hemochromatosis immunoglobulin therapy

More Related Videos

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
09:51

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Published on: January 27, 2023

1.8K
Isolation of Neonatal Extrahepatic Cholangiocytes
07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

10.3K

Related Experiment Videos

Last Updated: Aug 13, 2025

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.1K
Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
09:51

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Published on: January 27, 2023

1.8K
Isolation of Neonatal Extrahepatic Cholangiocytes
07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

10.3K

Area of Science:

  • Pediatric Hepatology
  • Neonatal Medicine
  • Immunology

Background:

  • Neonatal acute liver failure (NALF) presents a diagnostic challenge, with diverse potential etiologies including infectious, metabolic, genetic, and immune factors.
  • Gestational alloimmune liver disease (GALD) is an uncommon yet severe cause of NALF, characterized by antenatal onset and hepatic failure.

Observation:

  • A newborn presented with antenatal onset of hepatic failure, undergoing extensive etiological investigation.
  • Initial management focused on iron overload, but a lack of definitive diagnosis and response to supportive care prompted further investigation.
  • Characteristic features suggestive of GALD were observed, leading to the initiation of intravenous immunoglobulin (IVIG) therapy.

Findings:

  • The case highlights the diagnostic difficulty in NALF, where GALD may be suspected despite incomplete etiological workup.
  • Intravenous immunoglobulin (IVIG) therapy was administered, although its precise role in altering GALD prognosis and its underlying pathophysiology require further elucidation.
  • The study suggests considering immunoglobulin or exchange transfusion therapy early in severe perinatal hepatic failure of unknown etiology.

Implications:

  • Prompt therapeutic intervention, including IVIG, may be crucial for improving survival and clinical outcomes in newborns with suspected GALD.
  • This case underscores the importance of considering GALD in the differential diagnosis of NALF, even before all etiological investigations are finalized.
  • Further research is needed to clarify the exact etiology and pathophysiology of GALD and to optimize therapeutic strategies.