Static Magnetic Fields Protect against Cisplatin-Induced Kidney Toxicity

Area of Science:

• Biophysics
• Oncology
• Nephrology

Background:

• Cisplatin is a vital anti-cancer drug, but its use is limited by severe kidney toxicity.
• This nephrotoxicity stems from cisplatin-induced oxidative stress, inflammation, and apoptosis in renal cells.

Purpose of the Study:

• To investigate the potential of static magnetic fields (SMFs) to alleviate cisplatin-induced kidney toxicity.
• To elucidate the underlying mechanisms of SMF-mediated protection against nephrotoxicity.

Main Methods:

• Utilized moderate quasi-uniform static magnetic fields (SMFs) in both in vitro and in vivo models.
• Conducted RNA-sequencing (RNA-seq) to analyze gene expression changes induced by SMFs.
• Assessed kidney injury markers, oxidative stress, inflammation, and cisplatin concentration in treated mice.

Main Results:

• SMFs, particularly vertically downward fields, inhibited cisplatin-induced renal proximal tubular cell death.
• RNA-seq revealed SMF-modulated genes involved in oxidative stress, apoptosis, and DNA repair.
• In vivo studies demonstrated SMF treatment reduced kidney injury, oxidative stress, and inflammation in tumor-bearing mice.
• SMF therapy significantly lowered reactive oxygen species levels, prolonged survival, and reduced kidney cisplatin concentration.

Conclusions:

• Moderate SMFs represent a novel physical approach to counteract cisplatin-induced nephrotoxicity.
• SMF treatment effectively reduces oxidative stress and inflammation, offering a promising strategy to enhance the safety of cisplatin-based cancer therapy.