Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

33.5K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.5K
Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

63
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
63
Physiology of Urine Formation01:24

Physiology of Urine Formation

5.4K
Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocol for Developing and Validating a Multimarker-Clinical Prediction Model of SGLT2 Inhibitor-Induced Acute eGFR Dip in CKD Stages 3-4: A Three-Stage Urinary Proteomics Study.

Life (Basel, Switzerland)·2026
Same author

Investigations on the Multicentered Active Sites of Ziegler-Natta Polypropylene Catalysts through Multi-Models of the MgCl<sub>2</sub> Support.

ACS omega·2026
Same author

A persistent germylyne radical enabling reversible σ-dimerization and diverse bond activation.

Nature communications·2026
Same author

Analysis of Urinary Proteome Modifications in Patients with Different Glycated Hemoglobin A1c Levels.

International journal of molecular sciences·2026
Same author

Development and validation of machine learning models for predicting acute kidney injury in acute-on-chronic liver failure: a multimodel comparative study.

Renal failure·2026
Same author

Exploring the Effects of Teas with Different Fermentation Levels and Black Coffee on the Body via the Urine Proteome.

Nutrients·2026

Related Experiment Video

Updated: Aug 13, 2025

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
05:17

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy

Published on: April 5, 2024

875

Urinary Proteome Changes during Pregnancy in Rats.

Shuxuan Tang1, Youhe Gao1

  • 1Gene Engineering Drug and Biotechnology Beijing Key Laboratory, College of Life Sciences, Beijing Normal University, Beijing 100875, China.

Biomolecules
|January 21, 2023
PubMed
Summary

The study shows that urine analysis can reveal pregnancy progression and fetal development in rats. Urinary proteome profiling detected key developmental events earlier than traditional methods.

Keywords:
coagulation pathwayembryonic developmentpregnancyurinary proteome

More Related Videos

Ultrasonography in Experimental Reproductive Investigations on Rats
07:59

Ultrasonography in Experimental Reproductive Investigations on Rats

Published on: December 2, 2017

14.4K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

255

Related Experiment Videos

Last Updated: Aug 13, 2025

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
05:17

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy

Published on: April 5, 2024

875
Ultrasonography in Experimental Reproductive Investigations on Rats
07:59

Ultrasonography in Experimental Reproductive Investigations on Rats

Published on: December 2, 2017

14.4K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

255

Area of Science:

  • Biochemistry
  • Proteomics
  • Reproductive Biology

Background:

  • Pregnancy involves significant maternal physiological changes.
  • A normal pregnancy is critical for healthy maternal and fetal outcomes.
  • The urinary proteome's potential to reflect pregnancy is largely unexplored.

Purpose of the Study:

  • To investigate if the urinary proteome can serve as a non-invasive biomarker for the pregnancy process.
  • To correlate urinary protein changes with specific stages of maternal and fetal development in rats.

Main Methods:

  • Urine samples were collected from pregnant and control rats across different gestational days.
  • Urinary proteome profiling was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
  • Differential proteins were identified by comparing samples to gestational day 1 within each group.

Main Results:

  • Early pregnancy urine showed enrichment of pathways related to embryo implantation and trophoblast differentiation.
  • Maternal urinary proteome reflected fetal organ development (liver, kidney, bone, heart) and pancreatic development.
  • Surfactant appearance in urine preceded birth, and coagulation pathways increased before labor.
  • Urinary proteome detection of developmental events occurred earlier than microscopy-based observations.

Conclusions:

  • The maternal urinary proteome accurately reflects the physiological process of pregnancy and fetal development in rats.
  • Urinary proteome analysis offers a promising, non-invasive method for monitoring pregnancy.
  • This approach provides earlier insights into developmental milestones compared to traditional histological methods.