Related Experiment Video

Updated: Aug 13, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Published on: June 14, 2016

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The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms

Jia Liu1,2, Faping Wang1,2, Fengming Luo1,2

  • 1Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

Biomolecules
|January 21, 2023
PubMed

Insights

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway regulates cell functions and is implicated in diseases. This review explores its role in fibrotic diseases, suggesting JAK/STAT as a potential therapeutic target.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Pathophysiology

Background:

  • The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is a crucial signaling cascade involved in numerous cellular processes.
  • This pathway is activated by various extracellular signals including hormones, cytokines, and growth factors.
  • Dysregulation of JAK/STAT signaling is linked to diverse conditions such as cancer, inflammation, and autoimmune disorders.

Purpose of the Study:

  • To review the multifaceted roles and underlying mechanisms of the JAK/STAT signaling pathway in the pathogenesis of fibrotic diseases.
  • To explore the potential of targeting the JAK/STAT pathway for therapeutic interventions in organ fibrosis.

Main Methods:

  • Literature review of studies investigating JAK/STAT signaling in fibrotic conditions.
  • Analysis of existing data on JAK inhibitors in treating fibrotic diseases.

Main Results:

  • The JAK/STAT pathway plays a significant role in mediating cellular processes relevant to fibrosis across multiple organs (liver, kidney, heart, bone marrow, lung).
  • JAK inhibitors have demonstrated efficacy in treating myelofibrosis, indicating therapeutic potential.
  • Emerging evidence highlights the involvement of JAK/STAT in the pathophysiology of various fibrotic diseases.

Conclusions:

  • The JAK/STAT signaling pathway is a key player in the development and progression of fibrotic diseases.
  • Targeting the JAK/STAT pathway represents a promising therapeutic strategy for managing organ fibrosis.
Keywords:
Janus kinases (JAK)cytokinesfibroblastfibrosisinhibitorsignal transducer and activator of transcription (STAT)

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