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FK506-Binding Protein 2 Participates in Proinsulin Folding.

Carolin Hoefner1, Tenna Holgersen Bryde1,2, Celina Pihl1

  • 1Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

Biomolecules
|January 21, 2023
PubMed
Summary

FK506-binding protein 2 (FKBP2) is crucial for correct proinsulin folding by catalyzing proline isomerization. Its absence leads to misfolded proteins, reduced insulin, and increased pancreatic cell death, suggesting a role in type 2 diabetes.

Keywords:
FKBP2endoplasmic reticulumproinsulinproline isomerization

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