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Basic fibroblast growth factor is present in cultured human retinoblastoma cells
L Schweigerer1, G Neufeld, D Gospodarowicz
1Cancer Research Institute M-1282, University of California Medical Center, San Francisco 94143.
Investigative Ophthalmology & Visual Science
|November 1, 1987
Abstract:
Cultured human retinoblastoma cells express the basic fibroblast growth factor (bFGF) gene and they produce material similar, if not identical, to bFGF. The retinoblastoma-derived bFGF can stimulate the proliferation of capillary endothelial cells and this process is inhibited by anti-bFGF antibodies. It is conceivable that the retinoblastoma-derived bFGF contributes to the neovascularization of retinoblastomas.