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Engineering Advanced Drug Delivery Systems for Dry Eye: A Review
Tian-Zuo Wang1,2, Xin-Xin Liu1,2, Si-Yu Wang1,3
1State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325027, China.
Bioengineering (Basel, Switzerland)
|January 21, 2023
Summary
New drug delivery systems offer improved treatments for dry eye disease (DED). These advanced formulations enhance ocular drug penetration and action time, addressing limitations of current topical therapies for better DED management.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Biomaterials
Background:
- Dry eye disease (DED) is a prevalent multifactorial ocular condition causing discomfort and ocular surface damage.
- Topical administration is the primary treatment for DED, but faces challenges due to biological barriers limiting drug efficacy.
- Short drug action times and poor ocular penetration hinder effective management of DED with conventional methods.
Purpose of the Study:
- To review and discuss novel drug delivery systems for dry eye disease (DED) treatment.
- To analyze the characteristics, advantages, and deficiencies of innovative DED formulations.
- To explore the potential of advanced drug delivery systems in improving DED management.
Main Methods:
- Literature review of current and investigational drug delivery systems for DED.
- Analysis of formulation characteristics, including ocular penetration and sustained release.
- Evaluation of market-available and clinically studied advanced dosage forms.
Main Results:
- Advanced drug delivery systems show promise in overcoming ocular barriers for DED treatment.
- Innovative formulations like nanoparticles, liposomes, and in-situ gels offer enhanced drug delivery.
- Current advanced systems present unique advantages but also have specific limitations requiring further research.
Conclusions:
- Advanced drug delivery systems are crucial for overcoming the limitations of topical treatments in DED.
- The development of novel formulations is expected to significantly improve the clinical management of dry eye disease.
- Further research into the efficacy and safety of these advanced systems will enhance patient outcomes for DED.
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