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Burden, Outcome, and Comorbidities of Extrahepatic Manifestations in Hepatitis C Virus Infection

Busara Songtanin1, Kenneth Nugent1

  • 1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Biology
|January 21, 2023
PubMed

Insights

Hepatitis C virus (HCV) causes liver disease and serious non-liver complications. New treatments offer a cure, but understanding and managing these extrahepatic manifestations remains crucial.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis C virus (HCV) infection leads to chronic liver disease, cirrhosis, and hepatocellular carcinoma.
  • HCV is linked to significant extrahepatic manifestations (EHMs) like cryoglobulinemia, diabetes, and lymphoma.
  • These EHMs increase disease complexity, mortality, and healthcare costs globally.

Purpose of the Study:

  • To provide an updated review of HCV-associated extrahepatic manifestations.
  • To highlight the prevalence, risk factors, and disease burden of HCV EHMs.
  • To discuss current treatment strategies for managing HCV EHMs.

Main Methods:

  • Literature review of studies on Hepatitis C virus and its extrahepatic manifestations.
  • Analysis of prevalence, risk factors, and clinical impact of HCV-associated EHMs.
  • Synthesis of information on treatment outcomes and management of these conditions.

Main Results:

  • Direct-acting antiviral agents (DAAs) achieve high cure rates and reduce EHM burden.
  • Despite effective treatment, HCV EHMs remain a significant clinical concern.
  • Understanding viral mechanisms driving EHMs is essential for comprehensive patient care.

Conclusions:

  • HCV treatment with DAAs has improved outcomes by reducing EHM incidence and severity.
  • Continued research is needed to fully elucidate the pathogenesis of HCV EHMs.
  • Managing EHMs is vital for improving the quality of life and survival of HCV patients.

Keywords:
antiviral therapyburdenextrahepatic manifestationhepatitis C infectionhepatitis C virusmorbiditymortality

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