Bioadhesive Gauze Embedded with Chitosan-Butein Bioconjugate: A Redox-Active pH Sensor Platform

Area of Science:

• Biomaterials Science
• Electrochemistry
• Wearable Sensors

Background:

• The growing wound care market necessitates advanced wearable sensor platforms.
• Chitosan, a functional group-rich material, shows promise for electrochemical biosensors.
• Redox-active materials are crucial for developing effective healthcare sensors.

Purpose of the Study:

• To develop a metal-free, redox-active bioconjugate for epidermal bioadhesive electrode material.
• To create a wearable pH sensor for wound site analysis.
• To utilize chitosan-butein (CSB) for electrochemical biosensing applications.

Main Methods:

• Fabrication of a chitosan-butein (CSB) bioconjugate.
• Development of a two-electrode system using CSB-modified carbon/silver chloride as the working electrode.
• Characterization of the sensor platform's topology and electrochemical properties using cyclic voltammetry.

Main Results:

• The CSB bioconjugate formed a stable, epidermal bioadhesive electrode material.
• Cyclic voltammetry confirmed a 2e-/2H+ transfer mechanism in the CSB-modified electrode.
• The fabricated sensor exhibited distinct potential differences across a pH range of 5 to 9.

Conclusions:

• The developed CSB-based sensor is a promising tool for real-time wound site pH monitoring.
• This metal-free, wearable sensor offers a novel approach to wound care diagnostics.
• The inherent redox activity of the CSB bioconjugate enables sensitive pH detection.